I have been taking Napreva for about 4 months now for chronic back pain due to scoliosis and a couple of compression fractures. I have been able to quit the ibuprofen as I find the Napreva twice a day ( sometimes 3 times a day) works just as well. Very happy with the performance of Napreva!

I am a former MMA professional who was forced to retire at forty-five because of my career. I fought professionally around the world for eighteen years and then opened and ran a 4200 sq ft MMA academy in Carmel, IN.

When my health began to fail, I was placed on high doses of morphine, opiates (including oxycodone and OxyContin), heavy-duty muscle relaxers, and more.

I was going to die. In fact, I overdosed at least four times. My Black Belt students banded together and bought my dojo. My wife and I sold our house to move to Oregon for medical care and cannabis. The first prescription written for me in Oregon was for cannabis. It has helped, and now I make my own oral tinctures using that.

The rest of my family lives in Virginia. I haven't been able to fly back to see them for years and have two precious granddaughters. One of whom turns ONE on December 27th, 2025. My wife was there without me for the birth. I could not fly.

With the drops you manufacture... I am looking at going 100% plant-based medicine. I'm even seriously looking at giving up my blood pressure medications. I have been forced, out here, to become my own best doctor.

I plan on doing baseline readings with this new product and will work with my doctor to safely come off those meds. And then I will do a fully documented review for your magnificent company.

I just purchased more Napreva PLUS products. I do feel it's important to "gently recommend" to your clients to allow the sublingual rest under the tongue for at least one minute. And, to use the drops on an empty stomach. That has been the sweet spot for me.

Everyone has a different physiology, and I found many of the negative reviews to be things posted by those who want instant gratification, which is ubiquitous within the United States of America.

Many blessings to everyone at Napreva! Because all of you have blessed me! And I WILL fly in to see my grandchildren this coming January! And, your product is perfectly legal to wake with me on the flight! You gave me the workaround I needed to help me have a better and happier life!

Todd Card

β-Caryophyllene (BCP) is a naturally occurring terpene found in black pepper, cloves, oregano, basil, rosemary, cinnamon, hops, and cannabis. What makes it especially interesting is that it’s the only known dietary terpene that directly activates the CB2 cannabinoid receptor, which is linked to immune and inflammatory regulation—without psychoactive effects.

Below are the well-supported and widely discussed health benefits of high levels of β-caryophyllene:

🌿 1. Powerful Anti-Inflammatory Effects

Activates CB2 receptors (immune system–focused)

Helps reduce systemic and localized inflammation

Studied for potential benefit in:

Arthritis

Inflammatory bowel disease

Chronic inflammatory pain

➡️ Unlike NSAIDs, it does not irritate the stomach.

🧠 2. Pain Relief (Analgesic)

Reduces neuropathic and inflammatory pain

May work synergistically with other cannabinoids or terpenes

Especially useful for:

Joint pain

Muscle pain

Nerve pain

➡️ Often described as pain relief without sedation.

🛡️ 3. Immune System Modulation

CB2 activation helps balance immune response

May reduce overactive immune reactions (autoimmune-related inflammation)

Shows promise in regulating cytokine release

😌 4. Anti-Anxiety & Stress Reduction

May lower stress response via:

Reduced inflammation in the nervous system

Interaction with endocannabinoid signaling

Does not impair cognition or alertness

➡️ Helpful for calm focus rather than drowsiness.

❤️ 5. Cardiovascular Protection

Anti-inflammatory action may:

Improve vascular function

Reduce oxidative stress

Early research suggests potential support for:

Blood pressure regulation

Reduced arterial inflammation

(Still an emerging area of research)

🍽️ 6. Metabolic & Gut Health Support

May help:

Reduce gut inflammation

Improve digestive comfort

Some evidence suggests benefit in metabolic syndrome models

Unlike many cannabinoids, does not strongly stimulate appetite

In some people, it may mildly suppress appetite

🦠 7. Antimicrobial & Antioxidant Properties

Demonstrates activity against:

Certain bacteria

Fungal strains

Acts as an antioxidant, helping protect cells from oxidative damage

🧪 8. Neuroprotective Potential

Reduces neuroinflammation

Being studied for potential roles in:

Alzheimer’s disease

Parkinson’s disease

General cognitive aging

🌱 Natural Sources High in β-Caryophyllene

Clove oil (very high)

Black pepper

Oregano

Cinnamon

Basil

Rosemary

Hops

Certain CBD products (especially full-spectrum)

⚠️ Safety Notes

Classified as GRAS (Generally Recognized As Safe) by the FDA

Non-intoxicating

High doses via essential oils should be diluted properly

Can mildly interact with medications that affect inflammation or blood pressure

🟢 Summary

High levels of β-caryophyllene are associated with:
✔ Reduced inflammation
✔ Pain relief
✔ Immune balance
✔ Anxiety reduction
✔ Gut and metabolic support
✔ Neuroprotective potential

______________________________________________________________________________

Here are the health benefits associated with high levels of humulene, based on current research (mostly preclinical and traditional use):

🌿 Potential Health Benefits of Humulene
🔥 Anti-inflammatory effects

Humulene has been shown to reduce inflammatory markers (like TNF-α and IL-1β) in animal and cell studies.

May help with joint discomfort, muscle soreness, and inflammatory conditions.

Often works synergistically with β-caryophyllene, enhancing anti-inflammatory effects.

🦠 Antibacterial & antimicrobial

Demonstrates activity against certain bacteria and fungi.

One reason hops (rich in humulene) were traditionally used as a preservative in beer.

🍽️ Appetite-suppressing potential

Unlike many terpenes, humulene is associated with reduced appetite in some studies.

This is why it’s sometimes called the “diet terpene.”

May support weight management when combined with a balanced diet.

🧠 Mild calming & stress-modulating effects

Not sedating, but may promote a clear, grounded calm.

Often described as mentally stabilizing rather than euphoric.

🧬 Antioxidant activity

Helps neutralize free radicals, potentially supporting:

Cellular health

Immune resilience

Healthy aging

🩺 Possible anticancer properties (early research)

Lab studies suggest humulene may:

Inhibit tumor cell growth

Promote apoptosis (programmed cell death)

These findings are preclinical and not yet confirmed in humans.

🌱 Where High Humulene Levels Are Found

Hops (especially aroma hops)

Cloves

Basil

Sage

Ginseng

Some terpene-rich herbal extracts and essential oils

⚠️ Important Notes

Humulene is generally considered safe in food-level amounts.

Concentrated essential oils should be used with caution and never ingested undiluted.

*****This is the resea...

how can you really tell seems to walk better up n down stairs

While everyone is different I've found that Napreva works for me . While it doesn't eliminate the pain completely it does keep it in check .

Started using this with my 15 year old chihuahua-poodle and it has made a difference in easing his joint issues. He has struggled with arthritis for the last few years and was taking medication to help with pain and comfort. I have slowly weened him off the medication and have been using Nepreva for daily pain relief. We also use the CBd one at night for helping him settle and sleep as he has had a harder time in his old age.

Without going into any detail, I have pain 24/7,levels run between 3 and 10.
The past 10 yrs I have a condition call spondylolistheis, number 3 lumbar has sliped alinement with number 4 resulting in many nerves being put under much pressure and resulting Pain. Needless to say I have tried many OTC meds and alternatives and, a little tramadol, I do yoga 3 times a week and hit the gym for some uper body weights. Also I can walk 1/2 mile and do so everyday. all this is a big help in dealing with this on going situation.
I first ordered Na'preva a few weeks ago and found that it was going be to an effective pain reliefer. Then it became unavailable for over a month. I ordered a bottle when it became available and the results were the same, some pain relief.
My pain is'nt going to go away completely till I have the surgery and I'm just not ready for surgery, results can be less than good.
I just ordered 3 bottles (w/CBD) .
First thing in the mornings I use a theragun and then floor stretchs, next consume a dropper of Na'preva and then the pain is greatly reduced (last for 2-4 hrs) and I head out the door for the walk and gym on M-W-F and yoga on Tu-Th-Fri ( can't say enough about how yoga helps w/pain)
So, I speak form yrs of dealing with constant pain. You need to do the things that can offer some pain relief and forstall any surgury, Don't
just rely on Drs. and their harsh drugs.
I've made the switch from a conolidine product that delivered results
at twice the price of N'apreva. Both are effective but N'apeva is the better buy.
I would suggest you give N'apreva a try, it's affordable and will most likely give you some pain relief and, do walk and exercise, look into yoga.......

Works great for my arthuritis, plus lower back pain, I recommend this to anyone with the same issues, works great!!

This is my review of Napreva...
I have a history of chronic and very painful (24-7) back (lumber) issus, THis has been for the past 10 yrs. I have declined surgery for several reasons. I started with triger point injections, that did next to nothing. Over these past yrs I have tried countless OTC pain products. Some very expensive (100.00 for a sm jar), lidocaine patches and role on and, many other products.
Napreva w/CBD is the most effective product for pain relief that I have found.
No pain releif product is going to alleviate all my back pain. Napreva, taken in the morning on an emtpy stomach, allows me to head to the YMCA to walk on the treadmill and do some weights.
Napreva is my go to for pain relief. After 10 yrs + of trying everything, it proves to be the best yet pain reliefer...If it helps me, I'm sure it will help you with your pain situation.

It genuinely helps! I look forward to taking it each day and ordering more now! I'm a dance teacher with pain in shoulders, neck, and knees. Thank you!

Napreva has helped me with some of my discomfort and inflammation. My elbow had been bothering me for a while, aggravated by pickleball, and this not only helped me relaxed, but I'm now way more comfortable thanks to it. I hope they introduce more flavors.

Extremely well pleased. Fabulously works better than my pain medication. Thank you for this product. Fixing to order more. Thank you.

Napreva provides fast and lasting relief for my arthritis and nerve pain.

I have been a Napreva used since before Covid (2020). I was diagnosed as non-steroidal intolerant in 2002. I use this product for normal aches and pains (strained muscles, plantar fasciitis, headaches). I usually can feel relief in 5 minutes.

Napreva K9 has been a fantastic solution for my dog's persistent skin issues. She had been biting and itching a few spots on her side and back legs for years. Due to concerns about the potential extreme side effects of medications, we tried several natural products without success.

Within just 24 hours of her first dose of Napreva K9, we noticed a dramatic reduction in her biting. By the 48-hour mark, she had completely stopped scratching and biting altogether. Now, nearly two months later, she remains itch-free!

She wasn’t a big fan of the flavor at first, but we found a simple solution, mixing it with her favorite treats, dried salmon bits. She ate it right up with no hesitation.

I couldn’t be more impressed with the results. If you’re looking for a safe and effective remedy for your pet’s skin problems, I highly recommend Napreva K9!